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The psoriasis worry me the most are the ones that never respond to treatments. You've tried moisturizers, you've tried steroid creams, maybe even vitamin D creams, but it keeps exactly the same spot. Because sometimes, it isn't psoriasis at all. It could be Bowen's Disease. Bowen's disease, an early form of skin cancer, which can closely mimic psoriasis. The good news, Bowen's disease is very treatable when caught early.