Did you guys see that we have a new medication over the counter for pain?

Did you guys see that we have a new medication over the counter for pain? The FDA approved the first Tylenol and Naproxen combination product. So let's go through why you use something like this. So this honestly isn't the first time that we've combined an NSAID with Tylenol. This is literally the one I have at home, which is the Advil with Acetaminophen. The main difference? Is that with Advil Dual Action, you pretty much use this every eight hours. And that's because instead of Naproxen, the medication is Ibuprofen. But with this dosing because it has Naproxen, you're gonna be using this every 12 hours. So why would you want both of these ingredients when it comes to pain? Acetaminophen (Tylenol) Mechanism of Action. Primarily works in CENTRAL NERVOUS SYSTEM. COX. ↓ Prostaglandin synthesis in the brain. ↑ Pain threshold. Hypothalamus action. ↓ Fever. Minimal peripheral anti-inflammatory effect. proposed additional pathways. TRPV1-related effects. ACETAMINOPHEN MAINLY WORKS through central mechanisms. Fun fact, we actually don't really understand the pain mechanism, but pretty much just tells our brain to, like, not feel pain. Naproxen (Aleve) Mechanism of Action. NSAID Reversible COX-1 and COX-2 inhibition. Primarily works in PERIPHERAL TISSUES. Inflamed joint or tissue. Naproxen. How it works: Naproxen reversibly inhibits cyclooxygenase enzymes. COX-1, COX-2. Longer-acting NSAID 12-hour relief. Pain relief. Reduces pain signals at the source. Anti-inflammatory effect. Decreases swelling, redness, warmth, and irritation. Common NSAID risks: GI bleeding, kidney effects, cardiovascular warnings. Bottom line: Naproxen reduces PAIN blocking COX enzymes and. WORKS BY INHIBITING WHAT'S CALLED COX ENZYMES, WHICH IN TURN WILL DECREASE PROSTAGLANDINS THAT ARE CAUSING INFLAMMATION AND PAIN. So it's really important, you are taking you are not taking anything like Advil, Aleve, or Motrin, because doing that can increase your GI bleed. Comes to, like, cold medications, anything with Acetaminophen, we need to be careful of because of that risk for liver damage.