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Creatine is stable in cool water for hours But in hot, acidic drinks like coffee, it starts to break down faster into creatinine, a form your body can't really use. It's like buying organic vegetables and then deep frying them in motor oil. But here's what makes it even worse. Coffee isn't just hot, it's acidic, which means that it speeds up the process of breakdown. By the time you finish your cup, you've already lost a chunk of creatine's effect. Think about what you're doing. You spend $30 on quality creatine to build muscle just to waste it with your morning coffee. The lesson here is never mix creatine with anything hot. Take your coffee first, wait 30 minutes, then take creatine. Or just keep them separated. But here's what nobody tells you about creatine and water. Most people take their scoop with maybe one glass of water, but that's a huge mistake. Creatine is a water magnet. For every gram stored in muscle, it pulls in 3 to 4 grams of water. Now, think about this. You're already dehydrated. Coffee dehydrates you. Exercise dehydrates you. Just being alive uses water. Then creatine pulls even more away. Your blood becomes thick like syrup, and your kidneys work harder to filter everything. Go check your urine colour. I'm serious. Dark yellow or amber. You need more water. It should be pale and almost clear. If it looks like apple juice, you're in serious trouble. Remember that 18 year old with kidney damage? Although it was not proven, dehydration is a known factor in kidney stress. And here's the scary math nobody does. Normal person should drink two to three litres daily. Add creatine now, three to four litres. At exercise, four to five litres is minimum. You might need five to six litres. And here's the fix. If you can't drink this much water, stop taking creatine. Now, certain medications don't mix well with creatine. And the most common one is probably in your medicine cabinet right now. Ibuprofen, Advil and Motrin, the painkiller everyone takes. Now, let me explain this simply. Your kidneys need blood flow to work like a garden hose needs water pressure. Ibuprofen turns down that pressure. It's like stepping on the hose, so your kidneys are running on low pressure. Meanwhile, creatine makes your kidneys work harder. It's like asking someone to wash dishes faster while giving them less water. The dishes pile up, it's the same with your body. Here's what you need to know. One dose of ibuprofen won't destroy you. But if you're taking it multiple times a week with creatine, that's a problem. If you need regular pain relief, talk to your doctor. About acetaminophen, Tylenol. It works differently. About mixing creatine with energy drinks, keep it moderate. This combination puts serious stress on your system. Important note, if you take medication regularly, check with your doctor before starting creatine. A 20 year old woman, dry scooped pre-workout powder.