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Norepinephrine is the first-line vasopressor in septic shock, but knowing when to start it is only the beginning. This carousel breaks down the practical bedside details: how norepinephrine works, when to initiate it, starting doses and titration, peripheral administration, what to monitor, and what to do if extravasation occurs. One important point: you do not need to wait for a central line to start norepinephrine. When peripheral administration is necessary, use a reliable, preferably proximal, adequately sized IV and monitor the site closely. And if extravasation occurs: stop the infusion, leave the catheter in place initially to aspirate residual medication, and treat promptly according to your institutional protocol. Phentolamine is the classic antidote for norepinephrine extravasation. The goal isn’t simply getting the MAP above 65. It’s restoring adequate tissue perfusion while continually reassessing the patient. Based on current critical care literature and Surviving Sepsis Campaign guidance. Educational purposes only. #medicine #meded #medical #medtok #medstudent