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How to use azelaic acid and tretinoin like a dermatologist. I'm a board certified dermatologist in New York City. Azelaic acid and tretinoin have been trending everywhere and this is the best way to use it. Number one use azelaic acid in the morning. Azelaic acid is great for acne, hyperpigmentation, and rosacea, and it's one of the few creams that's actually safe to use during pregnancy. Little goes a long way and a thin layer is all you need. And always follow up with the sunscreen. Now tretinoin. Tretinoin is only for the night time. Tretinoin is a rockstar and it's great for fine lines and wrinkles, acne and acne scars, and texture skin. It's super important to know. Unlike azelaic acid, tretinoin is not safe to use during pregnancy. A pea size is all you need for the whole face. And start using it just once or twice a week so you get all the benefits without the irritation and purging. A thin layer is all you need. Don't forget the nose. And always follow up with a light moisturizer to keep your skin hydrated throughout the night. Remember azelaic acid in the morning and tretinoin at night and start glowing.