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A personalized mRNA cancer vaccine developed by Moderna and Merck, has achieved a major milestone in a late-stage clinical trial. Madison Muller Bloomberg News Combined with Merck's immunotherapy drug Keytruda, the custom shot helped reduce the recurrence of melanoma and slowed its spread to other parts of the body compared to Keytruda alone. Scientists analyzed each patient's tumor sample to create a tailored shot, targeting up to 34 unique mutations, training the immune system to hunt down remaining cancer cells. Wall Street reacted swiftly to the news. Moderna shares were up 100% when markets opened, the most since before the Covid pandemic, while Merck rose as much as 9.5% pandemic, while Merck rose as much as 9.5% The study provides the strongest evidence yet that mRNA technology can succeed beyond Covid-19 vaccines. The next test will be whether this success can translate to other types of cancers, as the companies hope.