Post by @onthewardsco

Pressors in septic shock can feel complicated until you understand what each one is actually doing. Norepinephrine is the first-line vasopressor, but what happens when your MAP still isn’t at goal? When should you add vasopressin? When does epinephrine come in? And where do agents like phenylephrine, dopamine, and angiotensin II fit? This post breaks down the major vasopressors used in septic shock, including receptor activity, when to start pressors, MAP targets, when to escalate therapy, and the important trade-offs between agents. The basic framework: Norepinephrine first → add vasopressin as norepinephrine requirements increase → add epinephrine if MAP remains inadequate. And remember, you don’t have to wait for central access to start treating hypotension. Vasopressors can be initiated through appropriate peripheral IV access when needed while definitive access is obtained. Based on the 2021 and 2026 Surviving Sepsis Campaign guidelines. For educational purposes only. Always follow your institution’s protocols and individualize management to the patient. #medstudent #MedTok #study #medicine #nurse